A new study has uncovered how an exceptionally scarce protein can orchestrate the assembly of large-scale gene-silencing structures inside cells, and what happens when that process breaks down. The ...

Single-molecule imaging shows that three CBX2 protein molecules can seed Polycomb condensates that silence genes in stem cells. The discovery reveals how rare proteins organize genome regulation and ...

Silence Therapeutics designs and develops siRNAs (short interfering RNAs) to address unmet patient need across a wide range of diseases with a genetic basis. In this interview with STAT Brand Studio, ...

University of Nottingham researchers have developed a highly tuneable materials platform that self-assembles with RNA to form ...

When cells divide and chromosomes are replicated for the daughter cells in a select type of cell called the germline, which is happening constantly in living things, sometimes things don’t go ...

Please provide your email address to receive an email when new articles are posted on . In this video, Mark Sulkowski, MD, discusses clinical trials in gene editing therapy and basic studies in ...

Gene knockdown is a common method for studying gene function by reducing messenger ribonucleic acid (mRNA) levels without altering the deoxyribonucleic acid (DNA). Among the available techniques, RNA ...

Schematic diagram illustrating the novel epigenetic pathway. The dual modification on histone variant H3.3 recruits CBX7, which brings the scaffold protein KAP1 to chromatin. KAP1 facilitates H3K9me3 ...

The evolution of biomedical science can be appreciated through studies of hemoglobin, the oxygen-carrying protein in red cells. Before molecular cloning, the geneticist Arno Motulsky noted, “Many ...

Arrowhead PharmaceuticalsARWR said Tuesday its gene-silencing approach delivered almost double the amount of weight loss over four months as Eli Lilly'sLLY Zepbound. The results boosted Arrowhead ...