We have developed a general experimental strategy that enables the quantitative detection of dynamic protein–protein interactions in intact living cells, based on protein-fragment complementation ...

Here, we report the results of our successful efforts to modify the DBO scaffold to extend its spectrum of activity to include coverage of a broad range of class D enzymes while further improving ...

Extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) have become a critical global public health challenge due to their high resistance to β-lactam antibiotics and association with severe ...

Council of Scientific and Industrial Research (India) has synthesized substituted tricyclic heterocyclic compounds acting as β-lactamase IMP-1 (bacterial) and/or New Delhi metallo-β-lactamase-1 (NDM-1 ...

See related research article by Kus and colleagues on page 1257 and at www.cmaj.ca/lookup/doi/10.1503/cmaj.110477. From a diagnostic and microbiologic perspective ...

Let us consider the following hypothetical scenario. A 48-year-old man with a history of type 2 diabetes mellitus was recently on vacation in Calcutta, India. Three days into his stay, he was involved ...

In the ongoing battle against antibiotic resistance, a new study published in Engineering by Zhuoren Ling’s research team unveils a promising triple combination of antibiotics that significantly ...

Tuojie Biotech (Shanghai) Co. Ltd. has disclosed boric acid derivatives acting as β-lactamase (bacterial) inhibitors reported to be useful for the treatment of bacterial infections.

Does piperacillin/tazobactam cover methicillin-sensitive Staphylococcus aureus (MSSA) infection? Or should we add a penicillinase-resistant penicillin to that ...