Bioluminescent RNA lanterns have revolutionized the way researchers track RNA activity within living organisms. In a groundbreaking study, scientists at the University of California, Irvine (UCI) ...

When a new memory forms the brain undergoes physical and functional changes known collectively as a “memory trace.” This memory trace represents the specific patterns of neuronal activity and ...

Computational models show that even subtle modifications in the synaptic protein CaMKII completely alter the resulting protein structures. Given how the formation and stability of these structures ...

Neurons have variable levels of chromatin compaction, shown as different shades of red. The less compact a neuron, the more likely it is to be recruited into the memory trace (green). When we form a ...

As animals experience new things, the connections between neurons, called synapses, strengthen or weaken in response to events and the activity they cause in the brain. Neuroscientists believe that ...

These biosensors give us a window into how these molecular switches behave in real time, at the level of single spines. By understanding which and how Rab proteins are regulated during synaptic ...

A new Nature Communications study reveals that mouse hippocampal CA3 circuits start life as dense, randomly connected networks before shedding many synapses to form sparse, organized structures suited ...

Working memory is a cognitive function that is essential for carrying out everyday activities and temporarily retaining information. This process enables us to understand information, learn and manage ...

In a study supported by the National Institutes of Health (NIH), researchers revealed the structural underpinnings of memory formation across a broad network of neurons in the mouse brain. This work ...

Complex protein interactions at synapses are essential for memory formation in our brains, but the mechanisms behind these processes remain poorly understood. Now, researchers have developed a ...