The Notch signalling network is a highly conserved cell–cell communication system that regulates cell fate, proliferation and differentiation throughout development and into adult tissue homeostasis.

In certain contexts, the Notch receptor may participate in “reverse signaling,” influencing neighboring cells directly.

A new paper published today in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key ...

Notch signalling is a highly conserved cell-to-cell communication pathway that orchestrates cell fate determination, proliferation and differentiation within the skeletal system. Activation occurs ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...