A sum of 921 samples were collected from three independent data sets. We obtained pyroptosis-related genes from both the Molecular Signatures Database and relevant literature sources and used four ...

Objective Macrophages and kidney cell pyroptosis/ferroptosis could play an important role in the pathogenesis of lupus ...

About 50% of the adult population throughout the world over the age of 70 years has chronic kidney disease (CKD) and renal fibrosis. Both CKD and renal fibrosis begin as pyroptosis, during which a ...

Pyroptosis is a proinflammatory type of cell death that is associated with gasdermin-mediated membrane hole formation, as well as cell enlargement and lysis. Pyroptosis plays an important role in both ...

This work was supported by grants from the National Natural Science Foundation of China (Nos. 82471497, 82311530117, and ...

Researchers report a new method for analyzing pyroptosis -- the process of cell death that is usually caused by infections and results in excess inflammation in the body -- and show that the process, ...

A novel pathological finding, "BABA", for a prognostic factor in oral tongue carcinoma. This is an ASCO Meeting Abstract from the ASCO Breakthrough: A Global Summit for Oncology Innovators. This ...

Promoting pyroptosis—an inflammatory form of programmed cell death—has become a promising treatment strategy for cancer. In research published in The FASEB Journal, investigators purified a long-chain ...

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A study led by Qun-Ying Lei shows that PGG inhibits the MAT2A enzyme activity while simultaneously promoting its degradation.