Nature

Involvement of cytochrome P450 3A4 and P-glycoprotein in first-pass intestinal extraction of omeprazole in rabbits

To quantitatively evaluate in vivo first-pass intestinal extraction of omeprazole and to investigate the possible involvement of cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) in this process ...
The New England Journal of Medicine

Primaquine Failure and Cytochrome P-450 2D6 in Plasmodium vivax Malaria

CYP2D6 phenotypes were ascertained in 25 available participants. The institutional review boards of the Walter Reed Army Institute of Research, the Naval Medical Research Center, and the Walter Reed ...
Nature

Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis

Many polyketide antibiotics contain macrolactones that arise from polyketide synthase chain release via thioesterase (TE) domain-catalyzed macrolactonization. The hydroxyl groups utilized in such ...
The New England Journal of Medicine

Genetic Determinants of Response to Warfarin during Initial Anticoagulation

Genetic variants of the enzyme that metabolizes warfarin, cytochrome P-450 2C9 (CYP2C9), and of a key pharmacologic target of warfarin, vitamin K epoxide reductase (VKORC1), contribute to differences ...
ascopubs.org

Patient-Tailored Antiemetic Treatment With 5-Hydroxytryptamine Type 3 Receptor Antagonists According to Cytochrome P-450 2D6 Genotypes

Superior Survival With Capecitabine Plus Docetaxel Combination Therapy in Anthracycline-Pretreated Patients With Advanced Breast Cancer: Phase III Trial Results PURPOSE: The use of serotonin ...